This paper addresses the sustainability of packaging in the fresh food supply chain by introducing a framework for designing integrated food packaging and distribution networks. Focusing on fresh produce, it compares traditional single-use packaging with reusable plastic containers (RPC) to assess economic and environmental impacts. Using Life Cycle Assessment (LCA), it evaluates the carbon footprint of packaging across the supply chain, with sensitivity analyses on factors like RPC lifespan, washing rate, waste treatment, and network geography. The findings offer insights into reducing environmental impact and suggest directions for future research.