This document outlines policy recommendations to advance reusable packaging systems in the U.S. In line with Target 2 of the Pact’s 2025 Roadmap, which aims for 100% of plastic packaging to be reusable, recyclable, or compostable by 2025, the guidance addresses policy barriers and opportunities for reuse. It advocates for legislative and regulatory support to create a consistent framework that enables reuse innovation, fosters new jobs, and prioritises waste prevention over waste management. The document also highlights the role of businesses and other stakeholders in driving reuse policy and infrastructure development.